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Title
MDM2 controls the action of p53 tumor suppressor #158071133
Description
MDM2 violet, foreground binds to p53 blue. Thus, the tumor suppressor p53 cannot bind to DNA and trigger the self-destruction of the cell. In the cytoplasm, a domain of MDM2 and MDMX red add ubiquitin to p53 targeting it for destruction by proteasomes.MDM2 may be a target for cancer chemotherapy