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Title
The mitotic kinase NEK7 binds to inactive NRLP3 leading to the assembly and activation of the NLRP3 inflammasome #181178707
Description
From left to right: apo-NEK7 inactive, active NEK7, NE7 bound to NLRP3. .Inflammasomes elicit host defense inside cells by activating caspase-1 for cytokine maturation and cell death. Dysregulation of inflammation activation can lead to cancer, autoimmune and neurodegenerative diseases. Source: PDB entries 2WQM, 6NPY