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Title
Chimeric antigen receptor CAR therapy: Engineered receptor binds to PD-L1 on a cancer cell #253411338
Description
Engineered receptor light blue on the surface of a natural killer cell binds specifically to PD-L1 molecules red on a cancer cell. This activates a signal cascade in the NK cell leading to the segregation of vesicles that contain perforin and granzyme. The perforins build channels for the granzymes which enter the leukemia cell and activate finally the apoptosis cell death of the cancer